Latest technologies from The University of Arizona
Microcavity Surface Bioconjugation Using Unilamellar Lipid Membranes For Label Free, Ultrasensitive Detection Of Alzheimer's Biomarkers
Mon, 11 Mar 2019 11:07:58 GMT

This invention outlines a new way of preparing a microtoroid optical resonator for the purpose of detecting amyloid-β plaque. Traditional ways of surface functionalization leave roughness on the optical resonator, making it difficult to achieve a higher Q-factor. This invention provides a new way of smoothing the surface of a resonator so that ultrasensitive detection can be achieved, providing high Q-factors as well as reduced scattering loss which is important when detecting key biomarkers such as amyloid-β.

Background:

Optical resonators are a key component of biosensors that are used in many different applications. However, the resonator has to have a smooth surface to allow the capture of light at different wavelengths. The ability of a resonator to capture light effectively is referred to as its Q-factor (quality factor). Traditional ways of smoothing the surface of a resonator still leave too much residual roughness that leads to a lower q-factor, and thus less accurate detection of biomarkers.

 

Applications:

  • Biomarker detection for healthcare diagnostics and drug development
  • Defense/security applications to detect explosives, chemical weapons, drugs
  • Environmental biosensors for air/water quality
  • Detection of disease in agricultural/food products

Advantages:

  • Achieves better surface smoothness for an optical resonator
  • Better Q-factor, longer wavelengths
  • Better for the detection of biomarkers
  • Validated in Alzheimer's use case 
Integrated Frequency Locked Optical Whispering Evanescent Resonator (FLOWER) based on Raspberry Pi
Mon, 11 Mar 2019 13:08:15 GMT

Raspberry Pi is a card-sized mini-computer that acts as a data processing center that replaces the prior commercial frequency locking system. It greatly reduces the size and the weight of the FLOWER system, making it possible for the FLOWER system to be carried by people or mounted on a drone.

Background:

FLOWER (frequency locked optical whispering evanescent resonator) is a currently patented system (9,739,770B2) which can measure low concentrations of biological and chemical molecules down to the single molecule limit. Although FLOWER is able to sense low concentrations of molecules, it occupies a large footprint and currently fits on a 4’ x 6’ optical table in the lab. This technology miniaturizes FLOWER, making it lightweight and portable. 

Applications:

  • An instrument to detect individual biomedical nanoparticles
  • Remote sensing capabilities

Advantages:

  • More portable
  • Higher processing capability
  • Ability to connect to the internet
  • Ability to share data
  • Less expensive
Radial Fast Spin-Echo (FSE) MRI Pulse Sequence
Thu, 26 Feb 2015 13:34:34 GMT

This invention is a software method that combines radial imaging (taking MRI data radially--from the center, out) with fast spin-echo (FSE) imaging to create faster, more accurate images.

This technology has been demonstrated to effectively image human brains, abdominal regions, and livers.

Background: 
Magnetic Resonance Imaging (MRI) is a very useful tool for imaging inside the human body without having to do invasive surgery. Two of the drawbacks to MRI technology currently are low image resolution and the length of time required to image.

Applications:

  • Use with current MRI machines
  • Can be a good alternative to T2-weighted imaging

Advantages: 

  • Higher image resolution
  • Faster image times
  • Less sensitivity to motion artifacts
  • Better ability to detect lesions in the liver
An FPGA Implementation of a Gb/s OFDM Transmitter and Receiver for Fiber Telecommunication Applications
Wed, 17 Jun 2020 11:53:24 GMT

University of Arizona researchers have invented a Field-Programmable Gate Array (FPGA) implementation of Orthogonal Frequency Division Multiplexing (OFDM) transmitter (Tx) and receiver (Rx). The design has two variants. One for direct detection OFDM and one for coherent OFDM based on self-coherent reception. 

This technology will allow for easier, cheaper, and faster research method into OFDM transmitters and receivers in the real world. Currently there is no effective way to research OFDM transmitters and receivers. Rather than building the OFDM Tx and Rx, they can be built and studied in real world telecom scenarios. This will save time since the simulated OFDM Tx and Rx can be built much quicker. Instead of building a physical OFDM, a virtual one can be built which is more convenient and cheaper.
 

Background:

Orthogonal Frequency Division Multiplexing (OFDM) is a form of signal waveform or modulation that provides some significant advantages for data links. It is used for many of the latest wide bandwidth and high data rate wireless systems including Wi-Fi and cellular telecommunications. Field-programmable gate array (FPGA) is an integrated circuit designed to be configured by the user. They contain an array of programmable logic block that can be inter-wired in different configurations.

 

Applications:

  • Research of OFDM nodes
  • Direct detection OFDM
  • Coherent OFDM
  • Commercial OFDM IP development

Advantages:

  • Accurate simulation
  • Real-world results
  • Broadens research opportunities
  • Cost effective
A Photorefractive, High Refractive Optical Polymers from Styrenic Sulfide Monomers
Mon, 17 Sep 2018 14:47:12 GMT

Title: A photo-definable high refractive index optical polymer from styrenic sulfide monomers

 

Invention: This is a novel method to create optical polymer with regions of high and low refractive index.

 

Background: The inventors were motivated by large technological motivation for optical polymers that are low-cost and have variable refractive index, especially in telecommunication. They have demonstrated the synthesis of a new compound, a new type of polymer, which can be used on the fabrication of new optical devices.

  

Applications:

•       Novel way to make new polymers that can have variable refractive index

•       Create new optical devices

Advantages:

•       High refractive index

•       Refractive index is tunable during the polymerization process

 

 

 

 

Quantitative Large Area Binding Sensor For Detecting Biomarkers
Sat, 09 Mar 2019 16:36:54 GMT

Title:  Quantitative Large Area Binding Sensor For Detecting Biomarkers

 

Invention:  Researchers at the University of Arizona have developed a lens-free holographic microscope (LFHM) for observing and quantifying target biomarkers in a solution, including targets with a large dynamic range in concentration.  LFHM can be used to detect microscale targets (e.g., bacteria and cells) and nanoscale targets (e.g., viruses, DNA strands, and cancer biomarkers).

 

Advantages:

*  can image a large range of target sizes

*  accommodates a large dynamic range in concentration

*  has a large field of view

 

Applications:

*  cancer biomarker detection

 

 

Fast Volumetric Imaging Of Fluorescent Tissue Structures And Activities
Wed, 27 Mar 2019 13:11:59 GMT

Invention:

Researchers at the University of Arizona have developed a novel microscope imaging technique that generates high-resolution large-volume 3D images of tissue at subcellular resolution, and captures transient activities within the volume at 100 volume frames per second (vps).  The invention breaks away from the traditional plane-scanning approach and implements volumetric projection imaging instead.

 

Background:

In order to study complex dynamics of tissue in live animals, ideally the microscope needs to maintain the sub-micron resolution in deep tissue to resolve activities in subcellular structures, cover a large volume to analyze complex networks, and refresh the volumetric image at high speed to capture transient dynamics.  However, despite many processes, at present there are no known microscopic techniques that fully satisfy the need for resolution, penetration, volume and speed.

 

Applications:

•       Fast 3D subcellular imaging for organs, tissues, and other body parts

 

Advantages:

•       Intrinsic high 3D resolution

•       Simplified image processing

•       Faster frame rates; can accommodate movement in sample

•       Large image area/field of view

•       Twice the photon sensitivity for increased photon efficiency

 

 

Rayleigh-Raman Polychromatic Laser Guide Star
Wed, 25 Mar 2020 13:29:32 GMT

Title: Rayleigh-Raman Polychromatic Laser Guide

 

Invention: A Rayleigh-Raman polychromatic laser guide star is implemented in an adaptive optics system to allow for the measurement of the tilt at the wavelength of observation. This makes use of the dispersion of the refractive index of and on or more differential tilt measurements at multiple wavelengths returned from the Rayleigh-Raman spectrum. 

 

Background: Adaptive optics systems require wavefront tilt compensation. Existing tilt measurement systems rely on light from a source that traverses the medium in a single. Laser guide stars create a reference source anywhere in the field of view to enable a wavefront measurement through turbulence. However, many existing laser guide stars cannot act as a tilt measurement reference source due to the double pass nature of the reference light. The technology is an improvement upon current technologies and will allow for the measurement of the tilt at the wavelength of observation. This method is scalable and offers flexibility in selecting multiple lasers of different wavelengths to measure from.

 

Applications:

•       Satellite imaging

•       Advanced imaging systems

•       Free Space Optical communication

•       Laser weapons

 

Advantages:

•       Flexibility

•       Increased range

•       Scalability

 

A Broadband Apparatus for Generating and Sampling Polarization States
Thu, 15 May 2014 13:23:07 GMT

Invention

Researchers at the University of Arizona have developed thin-film polarization devices that generate and/or sample light-polarization states over a broad band (wide wavelength range) and over wide angles. The polarizers incorporate and exploit multiple polarization layer groups and can be integrated into a microarray and incorporated into a light source or a polarization camera.

Background

Polarization is one of the primary characteristics of light. Current polarizers can measure or create both linear and circularly polarized light, but they are limited to operating over a narrow range of wavelengths and angles. There is a need for for polarizer-based devices that are operable over wider ranges of wavelengths and angles.

Applications

  • Broadband imaging polarimetry
  • Polarized white light sources
  • Displays
  • Cameras

Advantages

  • Operates over broad range of wavelengths and angles
  • Pixelated structure is useful for displays and detectors
  • Individual pixels can have different polarizations across the array

Inventor

Stanley Pau

Contact

Kennedy Nyairo

KennedyN@tla.arizona.edu

Refer to Technology UA13-104

Dual Contrast Agents Improve Dynamic Contrast Enhancement Magnetic Resonance Imaging (DCE-MRI) of Vascular Permeability, Angiogenesis
Fri, 14 Sep 2012 16:20:31 GMT

Invention

Scientists at the University of Arizona have developed a contrast agent model for DCE-MRI that allows an MRI to selectively detect two contrast agents at the same time. This invention includes software that allows the reference agent model to be used with all DCE-MRI equipment. The reference agent model accounts for the variable blood flow and hematocrit in each patient. It improves an MRI's ability to monitor contrast agent concentration in even the tiniest blood vessels. This reference agent model was successfully tested with two fluorinated contrast agents, designed specifically for this imaging system, in a mouse model of breast cancer.

Background

Traditional Dynamic Contrast Enhancement Magnetic Resonance Imaging (DCE-MRI) technology can only recognize one contrast agent or imaging agent when measuring vascular permeability and angiogenesis in tumors. This imaging agent limitation inhibits the accuracy and efficacy of DCE-MRI tumor scans.

Applications

  • Pharmacokinetics (contrast agent uptake and elimination) assessment.
  • Tumor angiogenesis detection and monitoring.
  • Disease detection and diagnosis.
  • Organ function and treatment monitoring.

Advantages

  • Selectively detects two contrasting image agents, allowing clinicians to gather more information about a tumor in one scan
  • Reference agent model can be applied to all DCE imaging assessments, reducing the need for specialized equipment.
  • It improves an MRI's ability to monitor contrast agent concentration in even the tiniest blood vessels.
  • Allows for multiple measurements during the course of one scan, reducing costs and the number of tests patients need to undergo.

Inventors

Mark Pagel

Julio Cesar Cardenas Rodriguez

 

Solar generator with two-stage optical concentration onto PV cells
Wed, 29 Apr 2020 11:42:50 GMT

Title: Solar Generator with Two-Stage Optical Concentration Onto PV Cells

 

Invention: A photovoltaic (PV) solar power generator that leverages optical design principles to obtain high power conversion performance and the robustness of operation at lower cost.

 

Background: As competition continues to grow within the solar power market, more efficient and less costly solar power systems are in high demand. This technology addresses that demand by providing a high performance optical design that focuses light onto multi-junction PV cells, thereby increasing efficiency and reducing cost for the power generated.

 

Applications:

  • Small-to-medium scale solar power generation

 

Advantages:

  • Increased efficiency
  • Decreased cost of operation
  • Decreased cost of assembly
  • More robust sun-tracking

 

 

Obstetrics Critical Care VR Training Volume 1, Episodes 1 & 2
Mon, 13 Feb 2017 13:12:00 GMT

Title: Virtual Reality Technology Used to Provide Experiential Education in the Management of Obstetric Critical Care Emergencies

 

Invention: The invention is a series of educational videos created to be viewed with virtual reality (VR) technologies to provide an experiential learning experience specific to crisis management for obstetric care providers.

 

Background: VR technology is poised to be a disruptive technology that will change the education of health care. VR technology can empower faculty to teach with a focus on increasing resources on monitoring learning physicians in critical thinking, pattern recognition, situational awareness, and comprehensive care instead of didactic knowledge.

 

Applications:

  • Universities and community colleges
  • Academic hospitals
  • Video games
  • Distance learning

 

Advantages:

  • Provides an immersive "hands-on" experience
  • Helps to build practical experience with trial and error
  • Increases the number of students to faculty members

 

 

Graphical User Interface for Electrophysiology Studies in Small Animals
Tue, 19 Jan 2016 14:00:07 GMT

Title: Graphical User Interface (GUI) for Electrophysiology Studies

 

Invention: This technology presents a GUI in conjunction with software written for recording and storing signals related to electrophysiological studies. Once recorded, this data can be filtered, extracted, and mapped, in color, to visualize properties. Developed along with corresponding techniques used in rat electrophysiology studies, this technology may provide further insight before testing proceeds to human subjects.

 

Background: Nearly 2,000 electrophysiology labs in the U.S. and an expected 12 million atrial fibrillation patients by 2050 indicate that the market will continue to demand advanced EP devices that decrease ablation procedure times and improve success rates.

 

Applications:

  • Electrophysiological research, development, and testing
  • Medical electrophysiological monitoring
  • Quality assurance amongst non in-vivo uses where electrophysiology is still relevant
  • Potential for implementation in non-medical avenues such as educational institutions

 

Advantages:

  • Ability to test new drugs for arrhythmia risk and/or prevention
  • Easy to use GUI enables better research performance in the lab with minimal training
  • Clinically relevant color maps visualize properties of the tissue
  • Enhances understanding of electrophysiological behavior

 

Improved Assessments of Vascular Permeability Using a Linear Reference Region Model for Dynamic Contrast Enhancement Imaging Studies
Fri, 17 Feb 2012 14:48:26 GMT

Invention

The investigators have developed significant improvements to the Reference Region Model that uses the pharmacokinetics in a large region of muscle tissue as a reference for the tumor tissue; this is much easier to monitor compared to tiny blood vessels. Moreover, the standard Reference Region Model uses a non-linear fitting routine that is slow, depends on initial guesses of the parameters to be determined, and fails to analyze up to 40% of image pixels. The invention’s linear fitting routine for this model is ~60 times faster, does not require initial guesses, and precisely fits all image pixels, enabling the algorithm much more practical in clinical settings.

Background

Angiogenesis, or the growth of new blood vessels, is a hallmark of tumor biology. Rapidly growing tumors have blood vessels that are immature and incompletely developed, leading to "leaky" tumor vasculature with increased permeability relative to normal tissues. Anti-angiogenic chemotherapies are designed to decrease the growth of new blood vessels and decrease vascular permeability. A variety of non-invasive imaging methods, including optical imaging, PET and SPECT radionuclide imaging, and magnetic resonance imaging (MRI) can be used to temporally monitor the perfusion of an imaging contrast agent in the tumor tissue, known as Dynamic Contrast Enhancement (DCE) imaging. A variety of computational methods are used to analyze the DCE imaging results to measure the vascular permeability in tumors. DCE MRI, DCE PET, DCE SPECT, and DCE fluorescence imaging have each been developed to assess tumor angiogenesis.

DCE imaging is not routinely used in the clinic because monitoring the dynamic changes in the concentration of the imaging agent in tiny blood vessels has been difficult and variable blood flow and hematocrit can complicate the interpretation of results. To overcome this problem, other researchers have developed the Reference Region Model (RRM) for DCE imaging, which uses the uptake and wash-out of the agent in a large muscle tissue as a reference that replaces the Arterial Input Function of the tiny blood vessels. Because imaging large muscle tissue is technically much easier than imaging tiny blood vessels, the RRM is considered to be a major improvement for this methodology.

Application

  • The Reference Region Model for DCE imaging compares the pharmacokinetics of one agent in tumor and muscle tissues.

Advantages

  • The invention’s linear fitting routine for this model is ~60 times faster, does not require initial guesses, and precisely fits all image pixels;
  • This method overcomes the problems why DCE imaging is not routinely used in the clinic, i.e. because monitoring the dynamic changes in the concentration of the imaging agent in tiny blood vessels has been difficult and variable blood flow and hematocrit can complicate the interpretation of results;
  • Algorithm is fast, needing only a minute to analyze an image or 30 minutes to analyze a stack of images that cover the entire tissue volume;
  • Method doesn’t require a priori knowledge;
  • Algorithm converges to a solution for 100% of image pixels.

Inventor

Dr. Mark “Marty” Pagel

Contact

Rakhi Gibbons

Licensing Manger, Tech Launch Arizona

RakhiG@tla.arizona.edu

UA ID: UA12-084

Curved Combiner
Wed, 18 Mar 2020 11:30:12 GMT

Tech ID: UA19-055

Title: Curved Combiner

Invention: The Curved Combiner is an improvement on flat waveguide head-up (i.e. windshields) and near to eye displays (i.e. glasses). The curved nature of the present invention allows for image expansion and aesthetically pleasing hardware to be used in a diversified set of applications. The present invention contains three holograms to redirect or expand the light that passes through the curved waveguide. Each hologram has a different function to ensure that the image has no aberrations which can occur when using curved waveguides.

Background: Waveguides are currently being produced using flat glass pieces. The advantage of flat waveguides is the small chance of image aberrations when injecting an image through the waveguide. However, flat waveguides limit the opportunity for image expansion and real-world applications. Current systems are bulky and limit integration capabilities. To address this issue, the present invention describes a curvature of the waveguide. The curvature allows the invention to be integrated into more modern applications.

Applications:

• Car windshields

• Modern glasses

• Airplane canopies

• Ticket counters

• Smart windows

• Doors of ovens, refrigerators, & freezers

• Helmets

• Contact lenses

• Augmented Reality

• Retail store window

Advantages:

• Image expansion

• Curvature capability of screen

• Designability

• Aesthetic appeal

• Increased comfort for viewer

• Elimination of image distortion and aberrations in current waveguides 

 

Inverse Optical Design of the Human Eye
Wed, 18 Mar 2020 09:39:25 GMT

Background: Adaptive optics technology using wavefront sensors is currently making profound contributions to vision science and ophthalmology.  It provides eye specialists with superior techniques for studying and correcting human vision, and for the early detection and treatment of visual diseases.  Researchers at The University of Arizona and the National University of Ireland, Galway, are developing an innovative method to estimate the full set of patient-specific ocular parameters using wavefront sensors. This 'inverse optical design' method maps the entire eye and shows potential for very low uncertainties. It promises a complete patient-specific eye model, providing substantial improvements in vision science and ophthalmology such as vision correction, retinal imaging, and surgical procedures, enabling research and applications previously unapproachable.

Applications:
* Complete eye mapping to evaluate vision performance and quality and statistically compare variability between patients.
* In vivo gradient-index (GRIN) distribution and lenticular geometry of the crystalline lens as function of age and accommodation.
* Theoretical basis for vision correction of higher-order aberrations in laser refractive surgery or with corrective lenses.
* Developing data bases for clinical diagnosis of pathologies.
* Ocular surface misalignments, e.g. after implantation of lenses in cataract surgery.
* Geometrical parameters of any optical system, e.g., GRIN distribution in commercial lenses.

Advantages:
* Provide in vivo, non-invasive, complete mapping of the eye, revealing dozens of parameters essential to an accurate representation of the eye and its aberrations.
* Knowing an individual's real eye structure facilitates a broad range of vision science studies and treatments ongoing today.

The Technology: The 'inverse optical design' approach is the opposite of traditional optical design. Data consist of raw detector outputs from a Shack-Hartmann wavefront sensor, and parameters in the eye model are then determined via maximum-likelihood estimation methods.

Stage of Development: The technology has been reduced to practice.

Inventors: Prof. Harrison H. Barrett, Alexander V. Goncharov, Ph.D., and Julia A. Sakamoto

Status: US Patent No.:  7,832,864 issued on Nov. 16, 2010. The University is seeking companies interested in incorporating this technology into there optical testing equipment with application to vision correction, retinal imaging, and surgical procedures.

Refer to Case No. UA07-055

Tissue Characterization with Partial Volume Correction Using Highly Undersampled Data and a Joint Fitting Algorithm
Tue, 07 Feb 2012 15:47:59 GMT

Invention

This technology provides techniques to a fast and accurate parameter estimation in the presence of partial volume from MRI data acquired. A specific technique application for liver lesion imaging is provided in this disclosure. The inventors employ Joint Bi-Exponential Fitting (JBF) algorithm in context of T2 estimation for small structure determination within background, overcoming the partial volume effect.

Background

While MRI technical improvements have transformed this modality for clinical application over the past 15 years, there remains a number of pressing technical requirements for a more extensive use in clinical applications. A major aim in MRI development is the need to achieve shorter acquisition times, particularly for imaging tissues that move (as a result from physiological effects such as respiration) or in types of imaging where obtaining the required information involves long acquisition times rendering the method impractical under clinical conditions. The goal of quantitative imaging modalities is to estimate a parameter that is associated with a specific property of the sample being imaged. Because samples of clinical or industrial importance are typically made up of more than one component, parameter estimation typically involves algorithms that can handle multi-component data. Conventional multiple component parameter fitting algorithms, however, are affected by the level of noise in the measurement data set yielding large uncertainties of the estimated parameter.

Advantages

  • Yields accurate estimates with less data than conventional fitting methods.
  • Allows for better observation of focal liver lesions and liver parenchyma.

Applications

  • Specific technique application for liver lesion imaging.
  • Liver imaging
  • Proposed technique could have significance for applications including tumor characterization.

Inventor

Maria Altbach

 

Method for Reconstruction of Magnetic Resonance Images
Fri, 16 Apr 2010 11:08:45 GMT

Invention

This technology presents an improved Compressed Sensing (CS) method. This method analyzes every iteration in the CS reconstruction process and refines the solution. This process gives statistically more reliable solutions and provides for better reconstructed image quality with reduced signal to noise ratios. This method improves reconstruction times by 13X to 20X over conventional methods while providing more accurate results.

 

Background

Long-data acquisition times are problematic when performing Magnetic Resonance Imaging (MRI) diagnostics. These long data acquisition times result in the inefficient use of scarce MRI machines and increased patient discomfort. In a previous technology, a method called Compressed Sensing was described to improve upon these issues.

 

Advantages

  • Reduced time to generate an image 13X to 20X improvements
  • Improved image quality
  • Reduce signal to noise ratios
  • Gives statistically more reliable solution

 

Applications

  • Mechanical Resonance Imaging Machines

 

Inventor

Dr. Ali Bilgin

 

Contact

John Geikler

Licensing Manger, Tech Launch Arizona

JohnG@tla.arizona.edu

Refer to technology # UA10-056

T2 Relaxometry with Indirect Echo Compensation from Highly Undersampled Data
Thu, 24 May 2012 16:12:55 GMT

Background:  While MRI technical improvements have transformed this modality for clinical application over the past 15 years, there remains a number of pressing technical requirements for continued progress towards more extensive utilization in clinical applications. A major current aim in furthering MRI development and applications is the need to achieve shorter acquisition times, particularly for imaging tissues that move (as a result from physiological effects such as respiration) or in types of imaging (as is the case for parametric imaging) where obtaining the required information involves long acquisition times rendering the method impractical under clinical conditions.

 

The SEPG algorithm has been recently proposed for T2 estimation with indirect echo compensation, however, this algorithm is not capable of performing the estimation using highly undersampled data. Slice-resolve Extended Phase Graph (SEPG) signal model has been proposed to estimate decay curves that consider indirect echoes. The main problem of incorporating the SEPG approach into a model-based reconstruction (in order to obtain accurate T2 estimates from highly undersampled data) is that the signal model is highly non-linear.

 

Invention:  This invention enables accurate T2 estimation from highly undersampled data with indirect echo contamination. The technique is based on an iterative algorithm where the signalmodel (which is derived from a model that takes into account the presence of indirect echoes) is linearized using principal component analysis. The goal of the proposed SlicE Resolved ExteNd phAse graph baseD rEconstruction of principal component coefficient maps (SERENADE) algorithm is to obtain accurate T2 estimates from data acquired in a short period of time (as short as a breath hold). Currently there are a few algorithms capable of performing T2 estimation from highly undersampled data. These algorithms ignore the indirect echo contamination which results in T2 overestimation especially when non-180° refocusing pulses are prescribed (as in athe case in high field magnets).

 

Applications: The common denominator is to able to estimate a parameter called the T2 relaxation time in a very short period of time. Changes in T2 are Indicative of a wide variety of pathologies including inflammatory processes, tumor formation, iron deposition, etc. In the case of abdominal and cardiothoracic imaging the technique has a tremendous advantage because it allows for accurate T2 mapping (by compensating for the effects of indirect echoes) from data acquired in just a single breath hold. Currently, no other techniques are available to achieve this degree of acceleration when high temporal and spatial resolution is required for tissue characterization. Thus, the proposed technology could represent a considerable opportunity regarding commercial value, such as through licensing arrangements.

 

Advantages:

  • New technique enables accurate T2 estimation from highly undersampled data with indirect echo contamination;
  • SERENADE enables fast T2 estimation for any anatomy in the body;
  • Enables T2 mapping with non-180° refocusing pulses which is essential when working at high magnetic fields (eg, 3 T) or for cardiac imaging when short refocusing pulses are needed to shorten the acquisition window.
  • Primarily useful for abdominal and cardiothoracic applications where the imaging time is limited to a breath hold. 

Lead Inventor:  Maria Altbach

 

UA ID:  UA12-107
Motion-Compensated Compressed Sensing for Dynamic Imaging
Wed, 01 Dec 2010 13:21:17 GMT

Invention

This invention develops a model based on Compressed Sensing techniques for application in Magnetic Resonance Imaging (MRI), wherein MR images can be reconstructed from significantly reduced data sets. The invention provides methods for reconstruction of time-varying signals from limited number of measurements. MR images can be reconstructed from significantly reduced data sets. This is done using motion estimation and compensation techniques in CS models to reconstruct more accurate estimates of support for image sequences with substantial motion.

Background

The recently introduced Compressed Sensing (CS) theory explains how sparse or compressible signals can be reconstructed from far fewer samples than what was previously believed possible. The CS theory has attracted significant attention for applications such as Magnetic Resonance Imaging (MRI) where long acquisition times have been problematic. This is especially true for dynamic MRI applications where high spatio-temporal resolution is needed. For example, in cardiac cine MRI, it is desirable to acquire the whole cardiac volume within a single breath-hold in order to avoid artifacts due to respiratory motion. Conventional MRI techniques do not allow reconstruction of high resolution image sequences from such limited amount of data. Vaswani et al. recently proposed an extension of the CS framework to problems with partially known support (i.e. sparsity pattern). In their work, the problem of recursive reconstruction of time sequences of sparse signals was considered. Under the assumption that the support of the signal changes slowly over time, they proposed using the support of the previous frame as the "known" part of the support for the current frame. While this approach works well for image sequences with little or no motion, motion causes significant change in support between adjacent frames. In this invention, the inventors illustrate how motion estimation and compensation techniques can be used to reconstruct more accurate estimates of support for image sequences with substantial motion (such as cardiac MRI).

Applications

  • Long data acquisition times are problematic in MRI. The invention enables creation of MR
  • Useful in applications where high spatio-temporal resolution is needed, for example dynamic MRI.

Advantages

  • Faster MRI acquisition times.
  • Improved high spatio-temporal resolution for dynamic MRI imaging.
  • Provides more accurate estimates of support for image sequences with substantial motion.

Inventor

Dr. Ali Bilgin

 


rssfeedwidget.com